JDALLILAB

2024

• Development and Validation of Methodologies for the Identification of Specialized Pro-Resolving Lipid Mediators and Classic Eicosanoids in Biological Matrices.
  Dooley M, Saliani A, Dalli J.
• The endocannabinoid anandamide activates pro-resolving pathways in human primary macrophages by engaging both CB₂ and GPR18 receptors.
  Leuti A, Fava M, Forte G, Pellegrini N, Oddi S, Scipioni L, Gomez EA, Dalli J, Maccarrone M.
• An LGR6 frameshift variant abrogates receptor expression on select leukocyte subsets and is associated with viral infections.
  Gomez EA, De Matteis R, Udomjarumanee P, Munroe PB, Dalli J.
• Resolvin D2 prevents vascular remodeling, hypercontractility and endothelial dysfunction in obese hypertensive mice through modulation of vascular and proinflammatory factors.
  Rodrigues-Diez R, Ballesteros-Martinez C, Moreno-Carriles RM, Nistal F, Díaz Del Campo LS, Cachofeiro V, Dalli J, García-Redondo AB, Redondo JM, Salaices M, Briones AM.
• Resolvin T4 enhances macrophage cholesterol efflux to reduce vascular disease.
  Walker ME, De Matteis R, Perretti M, Dalli J.
• Efferocyte-Derived MCTRs Metabolically Prime Macrophages for Continual Efferocytosis via Rac1-Mediated Activation of Glycolysis.
  Koenis DS, de Matteis R, Rajeeve V, Cutillas P, Dalli J.

2023

• Arachidonate 15-lipoxygenase-mediated production of Resolvin D5_{n-3 DPA} abrogates pancreatic stellate cell-induced cancer cell invasion.
  Aguirre GA, Goulart MR; Barts Pancreas Tissue Bank; Dalli J, Kocher HM.
• The Annexin-A1 mimetic RTP-026 promotes acute cardioprotection through modulation of immune cell activation.
  Chen J, Oggero S, Cecconello C, Dalli J, Hayat H, Hjiej Andaloussi A, Sanni S, Jonassen TE, Perretti M.
• Reply to: Failure to apply standard limit-of-detection or limit-of-quantitation criteria to specialized pro-resolving mediator analysis incorrectly characterizes their presence in biological samples.
  Dalli J, Gomez EA.
• Stereoselective Synthesis, Pro-resolution, and Anti-inflammatory Actions of RvD5_n-3 DPA.
  Ervik K, Reinertsen AF, Koenis DS, Dalli J, Hansen TV.
• Maresin 1 activates brown adipose tissue and promotes browning of white adipose tissue in mice. Laura M. Laiglesia, Xavier Escoté, Neira Sáinz, Elisa Felix-Soriano, Eva Santamaría, María Collantes, Marta Fernández-Galilea, Ignacio Colón-Mesa, Leyre Martínez-Fernández, Tania Quesada-López, Sergio Quesada-Vázquez, Carlos Rodríguez-Ortigosa, José M. Arbones-Mainar, Ángela M. Valverde, J Alfredo Martínez, Jesmond Dalli, Laura Herrero, Silvia Lorente-Cebrián, Francesc Villarroya, María J. Moreno-Aliaga
• Pro-inflammatory and pro-resolving lipid mediators of inflammation in HIV: effect of aspirin intervention. Jesmond Dalli, Douglas Kitch, Meagan P O’Brien, Peter W Hunt, Nicholas Funderburg, Daniela Moisi, Amita Gupta, Todd T Brown, Phyllis C Tien, Judith A Aberg, Rupak Shivakoti
• Deletion of macrophage Gpr101 disrupts their phenotype and function dysregulating host immune responses in sterile and infectious inflammation. Magdalena B Flak, Duco S Koenis, Maria Gonzalez-Nunez, Ana Chopo-Pizarro, Jesmond Dalli

2022

• Resolvin D2 Attenuates Cardiovascular Damage in Angiotensin II-Induced Hypertension. Lucia S Díaz Del Campo, Ana B García-Redondo, Cristina Rodríguez, Carlos Zaragoza, Santiago Duro-Sánchez, Francesco Palmas, Angela de Benito-Bueno, Paula G Socuéllamos, Diego A Peraza, Raquel Rodrigues-Díez, Carmen Valenzuela, Jesmond Dalli, Mercedes Salaices, Ana M Briones
• Resolution Pharmacology: Focus on Pro-Resolving Annexin A1 and Lipid Mediators for Therapeutic Innovation in Inflammation. Mauro Perretti, Jesmond Dalli
• Distinct immune profiles of HIV-infected subjects are linked to specific lipid mediator signature. Magdalena Sips, Sarah Gerlo, Laura De Clercq, Esteban A Gomez, Romain A Colas, Jesmond Dalli, Linos Vandekerckhove
• Vagus nerve stimulation promotes resolution of inflammation by a mechanism that involves Alox15 and requires the α7nAChR subunit. April S Caravaca, Alessandro L Gallina, Laura Tarnawski, Vladimir S Shavva, Romain A Colas, Jesmond Dalli, Stephen G Malin, Henrik Hult, Hildur Arnardottir, Peder S Olofsson
• Polyunsaturated fatty acids and fatty acid-derived lipid mediators: Recent advances in the understanding of their biosynthesis, structures, and functions. Simon C Dyall, Laurence Balas, Nicolas G Bazan, J Thomas Brenna, Nan Chiang, Felipe da Costa Souza, Jesmond Dalli, Thierry Durand, Jean-Marie Galano, Pamela J Lein, Charles N Serhan, Ameer Y Taha.
• MCTR3 reprograms arthritic monocytes to upregulate Arginase-1 and exert pro-resolving and tissue-protective functions in experimental arthritis. Kimberly Pistorius, Lucy Ly, Patricia R Souza, Esteban A Gomez, Duco S Koenis, Ana R Rodriguez, Julie Foster, Jane Sosabowski, Mark Hopkinson, Vinothini Rajeeve, Bernd W Spur, Andrew Pitsillides, Costantino Pitzalis, Jesmond Dalli
• Utility of the Specialized Pro-Resolving Mediators as Diagnostic and Prognostic Biomarkers in Disease. Jesmond Dalli, Esteban Alberto Gomez, Charlotte Camille Jouvene
• Lipid mediator n-3 docosapentaenoic acid-derived protectin D1 enhances synaptic inhibition of hippocampal principal neurons by interaction with a G-protein-coupled receptor. Apostolos Mikroulis, Marco Ledri, Gabriele Ruffolo, Eleonora Palma, Günther Sperk, Jesmond Dalli, Annamaria Vezzani, Merab Kokaia
• Aspirin activates resolution pathways to reprogram T cell and macrophage responses in colitis-associated colorectal cancer. Roberta De Matteis, Magdalena B Flak, Maria Gonzalez-Nunez, Shani Austin-Williams, Francesco Palmas, Romain A Colas, Jesmond Dalli
• Lipoxins modulate neutrophil oxidative burst, integrin expression and lymphatic transmigration differentially in human health and atherosclerosis. Jamie D Kraft, Robert Blomgran, Ida Bergström, Matúš Soták, Madison Clark, Alankrita Rani, Meenu Rohini Rajan, Jesmond Dalli, Sofia Nyström, Marianne Quiding-Järbrink, Jonathan Bromberg, Per Skoog, Emma Börgeson
• Stereoselective Synthesis, Configurational Assignment and Biological Evaluations of the Lipid Mediator RvD2_{n-3 DPA}. Amalie F Reinertsen, Karoline G Primdahl, Roberta De Matteis, Jesmond Dalli, Trond V Hansen

2021

• 20-hydroxyeicosatetraenoic acid (20-HETE) is a pivotal endogenous ligand for TRPV1-mediated neurogenic inflammation in the skin. Alexander Hamers, Christopher P Primus, Charlotte Whitear, Nitin Ajit Kumar, Michael Masucci, Shanik A Montalvo Moreira, Krishnaraj Rathod, Jianmin Chen, Kristen Bubb, Romain Colas, Rayomand S Khambata, Jesmond Dalli, Amrita Ahluwalia
• Differential Lipid Mediator Involvement in the Different Forms of Genetic Frontotemporal Dementia: Novel Insights into Neuroinflammation. Aitana Sogorb-Esteve, Romain A Colas, Jesmond Dalli, Jonathan D Rohrer
• Dysregulated Maresin Concentrations in Plasma and Nasal Secretions From Patients With Chronic Rhinosinusitis, Issa Beegun, Duco S Koenis, Ghassan Alusi, Jesmond Dalli
• Dysregulated plasma lipid mediator profiles in critically ill COVID-19 patients, Francesco Palmas, Jennifer Clarke, Romain A Colas, Esteban A Gomez, Aoife Keogh, Maria Boylan, Natalie McEvoy, Oliver J McElvaney, Oisin McElvaney, Razi Alalqam, Noel G McElvaney, Gerard F Curley, Jesmond Dalli
• Disrupted Resolution Mechanisms Favor Altered Phagocyte Responses in Covid-19, Duco Koenis, Issa Beegun, Charlotte Jouvene, Gabriel Amador Aguirre, Patricia R Souza, Maria Gonzalez-Nunez, Lucy Ly, Kimberly Pistorius, Hemant M Kocher, William Ricketts, Gavin Thomas, Mauro Perretti, Ghassan Alusi, Paul Pfeffer, Jesmond Dalli
• 14,17,18-Trihydroxy-Eicosatetraenoic Acid: A Novel Pro-Resolving Lipid Mediator from Marine Microalgae, Hans Jagusch, Markus Werner, Duco Koenis, Jesmond Dalli, Oliver Werz, Georg Pohnert

• Loss of 15-lipoxygenase disrupts T _reg differentiation altering their pro-resolving functions, Raquel M Marques, Maria Gonzalez-Nunez , Mary E Walker, Esteban A Gomez, Romain A Colas, Trinidad Montero-Melendez, Mauro Perretti, Jesmond Dalli 

• Platelets orchestrate the resolution of pulmonary inflammation in mice by T reg cell repositioning and macrophage education, Jan Rossaint, Katharina Thomas, Sina Mersmann, Jennifer Skupski, Andreas Margraf, Tobias Tekath, Charlotte C Jouvene, Jesmond Dalli, Andres Hidalgo, Sven G Meuth, Oliver Soehnlein, Alexander Zarbock

• Splenic Nerve Neuromodulation Reduces Inflammation and Promotes Resolution in Chronically Implanted Pigs, David M Sokal, Alex McSloy, Matteo Donegà, Joseph Kirk, Romain A Colas, Nikola Dolezalova, Esteban A Gomez, Isha Gupta, Cathrine T Fjordbakk, Sebastien Ouchouche, Paul B Matteucci, Kristina Schlegel, Rizwan Bashirullah, Dirk Werling, Kim Harman, Alison Rowles, Refet Firat Yazicioglu, Jesmond Dalli, Daniel J Chew, Justin D Perkins

2020

• Protective activities of distinct omega-3 enriched oils are linked to their ability to upregulate specialized pro-resolving mediators, Agua Sobrino, Mary E Walker, Romain A Colas, Jesmond Dalli

• Blood pro-resolving mediators are linked with synovial pathology and are predictive of DMARD responsiveness in rheumatoid arthritis, Esteban A Gomez, Romain A Colas, Patricia R Souza, Rebecca Hands, Myles J Lewis, Conrad Bessant, Costantino Pitzalis, Jesmond Dalli

• Enzymatic studies with 3-oxa n-3 DPA. Pangopoulos MK, Nolsøe JMN, Antonsen SG, Colas RA, Dalli J, Aursnes M, Stenstrøm Y, Hansen TV

• The GPR40 Agonist GW9508 Enhances Neutrophil Function to Aid Bacterial Clearance During E. coli Infections, Patricia R Souza, Mary E Walker, Nicolas J Goulding, Jesmond Dalli, Mauro Perretti, Lucy V Norling

• Plant- and Fish-Derived n-3 PUFAs Suppress Citrobacter Rodentium-Induced Colonic Inflammation. Määttänen P, Lurz E, Botts SR, Wu RY, Robinson SC, Yeung CW, Colas R, Li B, Johnson-Henry KC, Surette ME, Dalli J, Sherman PM

• A combination of LCPUFA ameliorates airway inflammation in asthmatic mice by promoting pro-resolving effects and reducing adverse effects of EPA. Fussbroich D, Colas RA, Eickmeier O, Trischler J, Jerkic SP, Zimmermann K, Göpel A, Schwenger T, Schaible A, Henrich D, Baer P, Zielen S, Dalli J, Beermann C, Schubert R

2019

• Enriched Marine Oil Supplements Increase Peripheral Blood Specialized Pro-Resolving Mediators Concentrations and Reprogram Host Immune Responses: A Randomized Double-Blind Placebo-Controlled Study, Souza PR, Marques RM, Gómez EA, Colas RA, De Matteis R, Zak A, Patel M, Collier DJ, Dalli J

Press Release for Circulation Research paper

• GPR101 mediates the pro-resolving actions of RvD5n-3 DPA in arthritis and infections. Flak MB, Koenis DS, Sobrino A, Smith J, Pistorius K, Palmas F, Dalli J.

• Lipid mediators of inflammation and Resolution in individuals with tuberculosis and tuberculosis-Diabetes. Shivakoti R, Dalli J, Kadam D, Gaikwad S, Barthwal M, Colas RA, Mazzacuva F, Lokhande R, Dharmshale S, Bharadwaj R, Kagal A, Pradhan N, Deshmukh S, Atre S, Sahasrabudhe T, Kakrani A, Kulkarni V, Raskar S, Suryavanshi N, Chon S, Gupte A, Gupta A, Gupte N, Arriaga MB, Fukutani KF, Andrade BB, Golub JE, Mave V.

• Proresolving mediator profiles in cerebrospinal fluid are linked with disease severity and outcome in adults with tuberculous meningitis. Colas RA, Nhat LTH, Thuong NTT, Gómez EA, Ly L, Thanh HH, Mai NTH, Phu NH, Thwaites GE, Dalli J.

• Synthesis, Structural Confirmation, and Biosynthesis of 22-OH-PD1_{n-3 DPA}. Nesman JI, Gangestad Primdahl K, Tungen JE, Palmas F, Dalli J, Hansen TV

• Proresolving mediators LXB₄ and RvE1 regulate inflammation in stromal cells from patients with shoulder tendon tears. Dakin SG, Colas RA, Wheway K, Watkins B, Appleton L, Rees J, Gwilym S, Little C, Dalli J, Carr AJ

• Early increase of specialized pro-resolving lipid mediators in patients with ST-elevation myocardial infarction. Fosshaug LE, Colas RA, Anstensrud AK, Gregersen I, Nymo S, Sagen EL, Michelsen A, Vinge LE, Øie E, Gullestad L, Halvorsen B, Hansen TV, Aukrust P, Dalli J, Yndestad A.

• Inflammatory arthritis disrupts gut resolution mechanisms, promoting barrier breakdown by Porphyromonas gingivalis. Flak MB, Colas RA, Muñoz-Atienza E, Curtis MA, Dalli J, Pitzalis C

• A single injection of docosahexaenoic acid induces a pro-resolving lipid mediator profile in the injured tissue and a long-lasting reduction in neurological deficit after traumatic brain injury in mice. Thau-Zuchman O, Ingram R, Harvey GG, Cooke T, Palmas F, Pallier PN, Brook J, Priestley JV, Dalli J, Lopez-Tremoleda J, Michael-Titus AT

• Polyunsaturated fatty acids modify the extracellular vesicle membranes and increase the production of proresolving lipid mediators of human mesenchymal stromal cells. Holopainen M, Colas RA, Valkonen S, Tigistu-Sahle F, Hyvärinen K, Mazzacuva F, Lehenkari P, Käkelä R, Dalli J, Kerkelä E, Laitinen S.

• Resolvin D1 Attenuates the Organ Injury Associated With Experimental Hemorrhagic Shock. Sordi R, Chiazza F, Collotta D, Migliaretti G, Colas RA, Vulliamy P, Brohi K, Dalli J, Collino M, Thiemermann C

• Lipid mediators in platelet concentrate and extracellular vesicles: Molecular mechanisms from membrane glycerophospholipids to bioactive molecules. Valkonen S, Holopainen M, Colas RA, Impola U, Dalli J, Käkelä R, Siljander PR, Laitinen S

• 15-Epi-LXA₄ and MaR1 counter inflammation in stromal cells from patients with Achilles tendinopathy and rupture. Dakin SG, Colas RA, Newton J, Gwilym S, Jones N, Reid HAB, Wood S, Appleton L, Wheway K, Watkins B, Dalli J, Carr AJ

• Leukocytes from obese individuals exhibit an impaired SPM signature. López-Vicario C, Titos E, Walker ME, Alcaraz-Quiles J, Casulleras M, Durán-Güell M, Flores-Costa R, Pérez-Romero N, Forné M, Dalli J, Clària J.

• Resolving Inflammation – Synthesis, Configurational Assignment and Biological Evaluations of RvD1n-3 DPA. Tungen JE, Gerstmann L, Vik A, De Matteis R, Colas RA, Dalli J, Chiang N, Serhan CN, Kalesse M, Hansen TV.

2018

• Federica Frigerio, Giulia Pasqualini, Ilaria Craparotta, Sergio Marchini, Erwin A van Vliet, Patrick Foerch, Catherine Vandenplas, Karin Leclercq, Eleonora Aronica, Luca Porcu, Kimberly Pistorius, Romain A Colas, Trond V Hansen, Mauro Perretti, Rafal M Kaminski, Jesmond Dalli, Annamaria Vezzani. n-3 Docosapentaenoic acid-derived protectin D1 promotes resolution of neuroinflammation and arrests epileptogenesis. Brain. 2018 October 10;  awy247 https://doi.org/10.1093/brain/awy247

• Pistorius K, Souza PR, De Matteis R, Austin-Williams S, Primdahl KG, Vik A, Mazzacuva F, Colas RA, Marques RM, Hansen TV, Dalli J. PD_{n-3 DPA} Pathway Regulates Human Monocyte Differentiation and Macrophage Function.Cell Chem Biol. 2018 Jun 21;25(6):749-760.e9. doi: 10.1016/j.chembiol.2018.04.017.

• Dalli J, Serhan CN. Identification and structure elucidation of the pro-resolving mediators provides novel leads for resolution pharmacology. Br J Pharmacol. 2018 Apr 21. doi: 10.1111/bph.14336.

• Chiang N, Riley IR, Dalli J, Rodriguez AR, Spur BW, Serhan CN. New maresin conjugates in tissue regeneration pathway counters leukotriene D₄-stimulated vascular responses. FASEB J. 2018 Jul;32(7):4043-4052. doi: 10.1096/fj.201701493R.

• Chen J, Hamers AJP, Finsterbusch M, Massimo G, Zafar M, Corder R, Colas RA, Dalli J, Thiemermann C, Ahluwalia A. Endogenously generated arachidonate-derived ligands for TRPV1 induce cardiac protection in sepsis. FASEB J. 2018 Jul;32(7):3816-3831. doi: 10.1096/fj.201701303R.

• Colas RA, Souza PR, Walker ME, Burton M, Zasłona Z, Curtis AM, Marques RM, Dalli J. Impaired Production and Diurnal Regulation of Vascular RvD_{n-3 DPA} Increase Systemic Inflammation and Cardiovascular Disease. Circ Res. 2018 Mar 16;122(6):855-863. doi: 10.1161/CIRCRESAHA.117.312472.

• Dalli J, Colas RA, Walker ME, Serhan CN. Lipid Mediator Metabolomics Via LC-MS/MS Profiling and Analysis. Methods Mol Biol. 2018;1730:59-72. doi: 10.1007/978-1-4939-7592-1_4.

• Sulciner ML, Serhan CN, Gilligan MM, Mudge DK, Chang J, Gartung A, Lehner KA, Bielenberg DR, Schmidt B, Dalli J, Greene ER, Gus-Brautbar Y, Piwowarski J, Mammoto T, Zurakowski D, Perretti M, Sukhatme VP, Kaipainen A, Kieran MW, Huang S, Panigrahy D. Resolvins suppress tumor growth and enhance cancer therapy. J Exp Med. 2018 Jan 2;215(1):115-140. doi: 10.1084/jem.20170681.

• Dalli J, Serhan CN. Immunoresolvents signaling molecules at intersection between the brain and immune system. Curr Opin Immunol. 2018 Feb;50:48-54. doi: 10.1016/j.coi.2017.10.007.

2017

• Dakin SG, Ly L, Colas RA, Oppermann U, Wheway K, Watkins B, Dalli J, Carr AJ. Increased 15-PGDH expression leads to dysregulated resolution responses in stromal cells from patients with chronic tendinopathy. Sci Rep. 2017 Sep 8;7(1):11009. doi: 10.1038/s41598-017-11188-y.

• Walker ME, Souza PR, Colas RA, Dalli J. 13-Series resolvins mediate the leukocyte-platelet actions of atorvastatin and pravastatin in inflammatory arthritis. FASEB J. 2017 Aug;31(8):3636-3648. doi: 10.1096/fj.201700268.

• Dalli J. Does promoting resolution instead of inhibiting inflammation represent the new paradigm in treating infections? Mol Aspects Med. 2017 Dec;58:12-20. doi: 10.1016/j.mam.2017.03.007.

• Lee S, Nakahira K, Dalli J, Siempos II, Norris PC, Colas RA, Moon JS, Shinohara M, Hisata S, Howrylak JA, Suh GY, Ryter SW, Serhan CN, Choi AMK. NLRP3 Inflammasome Deficiency Protects against Microbial Sepsis via Increased Lipoxin B₄Synthesis. Am J Respir Crit Care Med. 2017 Sep 15;196(6):713-726. doi: 10.1164/rccm.201604-0892OC.

• Dalli J, Colas RA, Arnardottir H, Serhan CN. Vagal Regulation of Group 3 Innate Lymphoid Cells and the Immunoresolvent PCTR1 Controls Infection Resolution. Immunity. 2017 Jan 17;46(1):92-105. doi: 10.1016/j.immuni.2016.12.009.

• Freire MO, Dalli J, Serhan CN, Van Dyke TE. Neutrophil Resolvin E1 Receptor Expression and Function in Type 2 Diabetes. J Immunol. 2017 Jan 15;198(2):718-728. doi: 10.4049/jimmunol.1601543.

2016

• Colas RA, DalliJ, Chiang N, Vlasakov I, Sanger JM, Riley IR, Serhan CN. Identification and Actions of the Maresin 1 Metabolome in Infectious Inflammation. J Immunol. 2016 Dec 1;197(11):4444-4452.

• Rathod KS, Kapil V, Velmurugan S, Khambata RS, Siddique U, Khan S, Van Eijl S, Gee LC, Bansal J, Pitrola K, Shaw C, D’Acquisto F, Colas RA, Marelli-Berg F, Dalli J, Ahluwalia A. Accelerated resolution of inflammation underlies sex differences in inflammatory responses in humans. J Clin Invest. 2016 Nov 28. pii: 89429. doi: 10.1172/JCI89429.

• Dalli J, Vlasakov I, Riley IR, Rodriguez AR, Spur BW, Petasis NA, Chiang, N and Serhan CN. Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages. PNAS 2016 ; doi:10.1073/pnas.1607003113.

• Titos E, Rius B, López-Vicario C, Alcaraz-Quiles J, García-Alonso V, Lopategi A, Dalli J, Lozano JJ, Arroyo V, Delgado S, Serhan CN, Clària J. Signaling and Immunoresolving Actions of Resolvin D1 in Inflamed Human Visceral Adipose Tissue. J Immunol. 2016 Oct 15;197(8):3360-3370.

• Primdahl KG, Aursnes M, Walker ME, Colas RA, Serhan CN, Dalli J*, Hansen TV*, Vik A*. Synthesis of 13(R)-Hydroxy-7Z,10Z,13R,14E,16Z,19Z Docosapentaenoic Acid (13R-HDPA) and Its Biosynthetic Conversion to the 13-Series Resolvins. J Nat Prod. 2016 Oct 5.

• Arnardottir HH, Dalli J, Norling LV, Colas RA, Perretti M, Serhan CN. Resolvin D3 Is Dysregulated in Arthritis and Reduces Arthritic Inflammation. J Immunol. 2016 Sep 15;197(6):2362-8. doi: 10.4049/jimmunol.1502268.

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