Jesmond Dalli is a Reader in Molecular Pharmacology at the Barts and The London School of Medicine and Dentistry and Queen Mary University of London. He is also a Sir Henry Dale Fellow and Director of the Lipid Mediator Unit at the William Harvey Research Institute. He received a B.Sc (Hons) in chemistry and biology and an M.Sc in biology from the University of Malta. He then read for and completed a Ph.D at the William Harvey Research Institute, Queen Mary University of London with Prof. Mauro Perretti. Dr. Dalli subsequently moved to Prof. Charles N. Serhan’s laboratory at Harvard Medical school and the Brigham and Women’s Hospital where he held a faculty post and was the co-director of two NIH funded lipid mediator profiling cores.
Dr. Romain A. Colas is a Postdoctoral Fellow at the William Harvey Research Institute. He received a Master Degree in 2007, in structural and functional biochemistry from the university of Lyon. In 2010, he completed a Ph.D at the INSA of Lyon investigating the link between low-density lipoprotein lipid and lipid peroxide profiles and the increased cardiovascular risk events in diabetic patients. In 2011, he became a Postdoctoral fellow at the IMBL and investigated the actions of DHA intake on plasma and platelets lipid profiles and redox status in a context of type-2 diabetes as well as cystic fibrosis. In 2012, he joined Prof. Charles N. Serhan’s laboratory at Harvard Medical School where he contributed to the identification of a novel family of potent mediators derived from n-3 docosapentaenoic acid (DPA) and their biological actions as well as the elucidation of further metabolism of maresin 1. There, he trained in lipid mediators (LM) profiling using LC-MS-MS, RP-UV-HPLC and GC-MS techniques and was promoted to core co-leader of an NIH funded lipid mediator metabololipidomics core. In 2015, he joined Dr. Jesmond Dalli team at the WHRI where he currently investigates SPM actions in the context of rheumatoid arthritis.
Lucy Ly is a research technician at the Lipid mediator unit at Barts and The London School of Medicine and Dentistry and Queen Mary College. She graduated with honors from Queen Mary University then completed her masters at the Institute of Psychiatry, Kings College London. She worked as a research technician in the department of cardiology at St Georges University of London before completing her PhD with Professor Brian Austen. Her PhD involved the characterisation of the β-secretase amyloid precursor protein-cleaving enzyme-1 (BACE1) in Alzheimer’s disease. After completing her PhD, she took some time out to have a family and has since joined the Lipid mediator Unit with Dr Jesmond Dalli. Her research aims at elucidating the role of specialised proresolving mediators in promoting cartilage and bone regeneration in rheumatoid arthritis.
Raquel Marques is a biochemist, specialised in immunology. She received her degree in 2007 from the Faculty of Science, University of Porto, Portugal. In 2014, she completed her Ph.D. that aimed to understand the molecular and cellular immune mechanisms related to the pathogenesis of Rabbit Hemorrhagic Disease, with distinction, at the Institute of Biomedical Sciences Abel Salazar, University of Porto, and under the supervision of Prof. Paula Ferreira Proença. Since 2007, she worked as a researcher of the Unit for Multidisciplinary Research in Biomedicine University of Porto and contributed to the work of other colleagues (Dr. Andreia Santos in the project “Canine mammary tumours” and Dr. Luzia Teixeira in the project “Host immune response to N. caninum infection”).She has peer-reviewed publications in the top 10 veterinary sciences journals. The results that outcome from her research instigated her to study inflammation, specifically the mechanisms that are involved in resolution and failed resolution in the context of disease. This led her to join Dr. Jesmond Dalli and his team at William Harvey Research Institute, the Barts and The London School of Medicine and Dentistry and Queen Mary College, where she is a Postdoc Research Assistant since June 2016.
Patricia R S Souza is a Postdoctoral Research Assistant working with Dr Jesmond Dalli at the Barts and The London School of Medicine and Dentistry and Queen Mary College. She received a B.Sc (Hons) in Biochemistry and Immunology and an M.Sc in Microbiology from the Federal University of Minas Gerais/Brazil. She recently finished her PhD at the prestigious William Harvey Research Institute, Queen Mary University of London with Prof. Mauro Perretti, which focused in evaluating the mechanisms of the activation of G-coupled protein receptor 40 in immune cells and rheumatoid arthritis. Together with Dr Jesmond Dalli in the Lipid Mediator Unit she is investigating the role of SPM in regulating innate and adaptive immune responses as well as promoting tissue regeneration in rheumatoid arthritis.
Mary obtained a B.Sc (Hons) in Biochemistry from the University of Bristol and proceeded to work as a research assistant at the Bristol Cardiovascular Biomedical Research Unit. She then continued her studies in the lab of Dr. Jesmond Dalli as an M.Res student at the William Harvey Research Institute, Queen Mary University of London. She is currently a PhD student investigating the role of thirteen-series resolvins in inflammatory arthritis.
Kim Pistorius is a research technician in the Lipid Mediator Unit with Dr Jesmond Dalli. She is also reading for a PhD investigating the role of MCTR’s in tissue repair and regeneration. She obtained her BSc (Hons) and MSc in Biological Science at the University of KwaZulu-Natal, Durban, South Africa. In this time she was researching the effect of hypoxia in the South African abalone, focusing on the expression of the oxygen moderating protein hypoxia-inducible factor-1 (HIF-1) and its target gene, inducible nitric oxide synthase (iNOS).
Roberta De Matteis obtained a Bachelor of Science in Medical Biotechnology and subsequently a Master of Science in Medical Biotechnology and Molecular Medicine from the University of Milan. She then proceeded to work in the Immuno-Rheumatology lab under the supervision of Professor P. L. Meroni at the University of Milan – Istituto Auxologico Italiano with a Junior Researcher’s Fellowship. She worked as a Research Technician in Dr. Jesmond Dalli’s lab at the William Harvey Research Institute, Queen Mary University of London before beginning a PhD studentship in September 2018.
Francesco Palmas is a Postdoctoral Research Assistant at the Lipid Mediator Unit of the William Harvey Research Institute. In 2014, he received a Master’s Degree in Chemistry – Molecular Design, Synthesis, and Catalysis from the University of Amsterdam. He then continued with a PhD in Chemical Sciences and Technologies at the University of Cagliari, focusing on the metabolomic analysis of diverse bio-fluids in relation to different pathological/physiological conditions through GC-MS and NMR approaches. During his Master’s and PhD, he worked at Cheng Lab, Massachusetts General Hospital/Harvard Medical School, principally investigating renal cell carcinoma (RCC) by means of HR-MAS platform. Currently, Francesco is part of Dr. Jesmond Dalli’s team at the core of WHRI for LC-MS-based lipid mediator profiling.
Agua Sobrino is a Postdoctoral Research Assistant within the Lipid Mediator Unit. Dr. Sobrino obtained her degree in Biochemistry from the University of Valencia (Spain) in 2004. In 2006, she was awarded a PhD Government Spanish Fellowship in the Department of Physiology of the Faculty of Medicine to investigate the “Effect of Estradiol in global gene expression patterns of cultured human endothelial cells, and its role in blood pressure and vascular dysfunction” under Professor Carlos Hermenegildo. During this time she worked in Professor Elazer Edelman’s lab at Harvard-MIT Biomedical Engineering Center (BMEC) as part of her research study. She completed her PhD with Magna Cum Laude in 2011. After that, she obtained a European Postdoctoral FEBS fellowship in Carmeliet Lab at KU-Leuven/Center for Cancer Research (Belgium). She was involved in “Characterizing the role of glutamine metabolism in endothelial cells, and investigate[d] its role in cell proliferation and angiogenesis”. From 2013 to 2017 she joined Professor Christopher Hughes’s lab as Postdoctoral Fellow in the University of California, Irvine. She participated in the development of an integrated in-vitro model of perfused tumor and cardiac tissue and was responsible for drug therapy and metabolic studies.
Dr. Duco Koenis is a Postdoctoral Research Assistant at the Lipid Mediator Unit of the William Harvey Research Institute. He obtained his Bachelor of Science degree in Biomedical Sciences at the University of Amsterdam in 2010, and a Master of Science degree in Biomedical Sciences with a focus on Medical Biochemistry at the University of Amsterdam in 2013, graduating with distinction (cum laude). Following his Master’s studies, Duco started his PhD research at the Medical Biochemistry department of the Academic Medical Center in Amsterdam under the supervision of Prof. Dr. C.J.M. de Vries, where he studied the role of the nuclear receptor Nur77 in macrophage metabolism and inflammation. Duco started his current work with Dr. Jesmond Dalli’s group in July 2018.
Esteban Gomez Cifuentes is a bioinformatician at the Lipid Mediator Unit of the William Harvey Research Institute. He obtained a Bachelor Degree (2013) in Biological Engineering from Universidad Nacional de Colombia and then he pursued his Master Degree (2018) in Bioinformatics at Queen Mary University of London. During his professional life, he has worked in different research areas (immunology, drug development, genomics and evolution) always trying to create bioinformatics solutions to biological problems (database and algorithm development, big genomic data manipulation and statistical analysis). He is currently working in the Lipid Mediator Unit as a Research Technician in order to develop computational models, based on machine learning, capable of predicting the response of patients with inflammatory diseases to several treatments.
James Smith obtained a Bachelor of Science in Biochemistry from the University of Bath in 2018. As part of his undergraduate studies, he worked in Dr Paul Baldock’s Skeletal Metabolism lab at the Garvan Institute of Medical Research (Sydney) for a year, using RNA sequencing analysis to investigate the gene expression patterns of osteocyte cells in mice of different ages. Following his graduation, he joined Dr Jesmond Dalli’s group as a Research Technician in October 2018.
Ashley Cootes is Administrator of the Lipid Mediator Unit, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London. She has a Bachelor of Arts from University of Maryland and a Master of Arts from University of London and over ten years’ experience in higher education professional services. She joined Dr Dalli’s group in 2017.