Publications

Selected recent publications

2020

• Esteban A Gomez, Romain A Colas, Patricia R Souza, Rebecca Hands, Myles J Lewis, Conrad Bessant, Costantino Pitzalis, Jesmond Dalli. Blood pro-resolving mediators are linked with synovial pathology and are predictive of DMARD responsiveness in rheumatoid arthritis. Nat Commun. 2020 Oct 27;11(1):5420. doi: 10.1038/s41467-020-19176-z.

• Pangopoulos MK, Nolsøe JMN, Antonsen SG, Colas RA, Dalli J, Aursnes M, Stenstrøm Y, Hansen TV. Enzymatic studies with 3-oxa n-3 DPA. Bioorg Chem. 2020 Mar;96:103653. doi: 10.1016/j.bioorg.2020.103653. Epub 2020 Feb 8.
• Määttänen P, Lurz E, Botts SR, Wu RY, Robinson SC, Yeung CW, Colas R, Li B, Johnson-Henry KC, Surette ME, Dalli J, Sherman PM. Plant- and Fish-Derived n-3 PUFAs Suppress Citrobacter Rodentium-Induced Colonic Inflammation. Mol Nutr Food Res. 2020 Jan 16:e1900873. doi: 10.1002/mnfr.201900873. [Epub ahead of print]

• Fussbroich D, Colas RA, Eickmeier O, Trischler J, Jerkic SP, Zimmermann K, Göpel A, Schwenger T, Schaible A, Henrich D, Baer P, Zielen S, Dalli J, Beermann C, Schubert R. A combination of LCPUFA ameliorates airway inflammation in asthmatic mice by promoting pro-resolving effects and reducing adverse effects of EPA. Mucosal Immunol. 2020 Jan 6. doi: 10.1038/s41385-019-0245-2. [Epub ahead of print]

2019

• Souza PR, Marques RM, Gómez EA, Colas RA, De Matteis R, Zak A, Patel M, Collier DJ, Dalli J. Enriched Marine Oil Supplements Increase Peripheral Blood Specialized Pro-Resolving Mediators Concentrations and Reprogram Host Immune Responses: A Randomized Double-Blind Placebo-Controlled Study. Circulation Research. 12 Dec 2019.

Press Release for Circulation Research paper

• Flak MB, Koenis DS, Sobrino A, Smith J, Pistorius K, Palmas F, Dalli J. GPR101 mediates the pro-resolving actions of RvD5n-3 DPA in arthritis and infections. J Clin Invest. 2019 Dec 3. pii:131609. doi: 10.1172/JCI131609.

• Shivakoti R, Dalli J, Kadam D, Gaikwad S, Barthwal M, Colas RA, Mazzacuva F, Lokhande R, Dharmshale S, Bharadwaj R, Kagal A, Pradhan N, Deshmukh S, Atre S, Sahasrabudhe T, Kakrani A, Kulkarni V, Raskar S, Suryavanshi N, Chon S, Gupte A, Gupta A, Gupte N, Arriaga MB, Fukutani KF, Andrade BB, Golub JE, Mave V. Lipid mediators of inflammation and Resolution in individuals with tuberculosis and tuberculosis-Diabetes. Prostaglandins Other Lipid Mediat. 2019 Nov 11;147:106398. doi: 10.1016/j.prostaglandins.2019.106398.

• Colas RA, Nhat LTH, Thuong NTT, Gómez EA, Ly L, Thanh HH, Mai NTH, Phu NH, Thwaites GE, Dalli J. Proresolving mediator profiles in cerebrospinal fluid are linked with disease severity and outcome in adults with tuberculous meningitis. FASEB J. 2019 Sep 7:fj201901590R. doi: 10.1096/fj.201901590R.

• Nesman JI, Gangestad Primdahl K, Tungen JE, Palmas F, Dalli J, Hansen TV. Synthesis, Structural Confirmation, and Biosynthesis of 22-OH-PD1_{n-3 DPA}. Molecules. 2019 Sep 5;24(18). pii: E3228. doi: 10.3390/molecules24183228.

• Dakin SG, Colas RA, Wheway K, Watkins B, Appleton L, Rees J, Gwilym S, Little C, Dalli J, Carr AJ. Proresolving mediators LXB₄ and RvE1 regulate inflammation in stromal cells from patients with shoulder tendon tears. Am J Pathol. 2019 Aug 19. pii: S0002-9440(19)30667-4. doi: 10.1016/j.ajpath.2019.07.011

• Fosshaug LE, Colas RA, Anstensrud AK, Gregersen I, Nymo S, Sagen EL, Michelsen A, Vinge LE, Øie E, Gullestad L, Halvorsen B, Hansen TV, Aukrust P, Dalli J, Yndestad A. Early increase of specialized pro-resolving lipid mediators in patients with ST-elevation myocardial infarction. EBioMedicine. 2019 Jul 22. pii: S2352-3964(19)30459-1. doi: 10.1016/j.ebiom.2019.07.024.

• Flak MB, Colas RA, Muñoz-Atienza E, Curtis MA, Dalli J, Pitzalis C. Inflammatory arthritis disrupts gut resolution mechanisms, promoting barrier breakdown by Porphyromonas gingivalis. JCI Insight. 2019 Jul 11;4(13). pii: 125191. doi: 10.1172/jci.insight.125191. eCollection 2019 Jul 11.

• Thau-Zuchman O, Ingram R, Harvey GG, Cooke T, Palmas F, Pallier PN, Brook J, Priestley JV, Dalli J, Lopez-Tremoleda J, Michael-Titus AT. A single injection of docosahexaenoic acid induces a pro-resolving lipid mediator profile in the injured tissue and a long-lasting reduction in neurological deficit after traumatic brain injury in mice. J Neurotrauma. 2019 Jun 29. doi: 10.1089/neu.2019.6420.

• Holopainen M, Colas RA, Valkonen S, Tigistu-Sahle F, Hyvärinen K, Mazzacuva F, Lehenkari P, Käkelä R, Dalli J, Kerkelä E, Laitinen S. Polyunsaturated fatty acids modify the extracellular vesicle membranes and increase the production of proresolving lipid mediators of human mesenchymal stromal cells. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Jun 15;1864(10):1350-1362. doi: 10.1016/j.bbalip.2019.06.010.

• Sordi R, Chiazza F, Collotta D, Migliaretti G, Colas RA, Vulliamy P, Brohi K, Dalli J, Collino M, Thiemermann C. Resolvin D1 Attenuates the Organ Injury Associated With Experimental Hemorrhagic Shock. Ann Surg. 2019 Jun 7. doi: 10.1097/SLA.0000000000003407.

• Valkonen S, Holopainen M, Colas RA, Impola U, Dalli J, Käkelä R, Siljander PR, Laitinen S. Lipid mediators in platelet concentrate and extracellular vesicles: Molecular mechanisms from membrane glycerophospholipids to bioactive molecules. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Aug;1864(8):1168-1182. doi: 10.1016/j.bbalip.2019.03.011. Epub 2019 Apr 10.

• Dakin SG, Colas RA, Newton J, Gwilym S, Jones N, Reid HAB, Wood S, Appleton L, Wheway K, Watkins B, Dalli J, Carr AJ. 15-Epi-LXA₄ and MaR1 counter inflammation in stromal cells from patients with Achilles tendinopathy and rupture. FASEB J. 2019 Jul;33(7):8043-8054. doi: 10.1096/fj.201900196R. Epub 2019 Mar 27.

• López-Vicario C, Titos E, Walker ME, Alcaraz-Quiles J, Casulleras M, Durán-Güell M, Flores-Costa R, Pérez-Romero N, Forné M, Dalli J, Clària J. Leukocytes from obese individuals exhibit an impaired SPM signature. FASEB J.  2019 Jul;33(7):8043-8054. doi: 10.1096/fj.201900196R. Epub 2019 Mar 27.

• Tungen JE, Gerstmann L, Vik A, De Matteis R, Colas RA, Dalli J, Chiang N, Serhan CN, Kalesse M, Hansen TV. Resolving Inflammation – Synthesis, Configurational Assignment and Biological Evaluations of RvD1n-3 DPA. Chemistry. 2018 January 28;25(6):1476-1480. doi: 10.1002/chem.201806029. Epub 2018 Dec 20.

2018

• Federica Frigerio, Giulia Pasqualini, Ilaria Craparotta, Sergio Marchini, Erwin A van Vliet, Patrick Foerch, Catherine Vandenplas, Karin Leclercq, Eleonora Aronica, Luca Porcu, Kimberly Pistorius, Romain A Colas, Trond V Hansen, Mauro Perretti, Rafal M Kaminski, Jesmond Dalli, Annamaria Vezzani. n-3 Docosapentaenoic acid-derived protectin D1 promotes resolution of neuroinflammation and arrests epileptogenesis. Brain. 2018 October 10;  awy247 https://doi.org/10.1093/brain/awy247

• Pistorius K, Souza PR, De Matteis R, Austin-Williams S, Primdahl KG, Vik A, Mazzacuva F, Colas RA, Marques RM, Hansen TV, Dalli J. PD_{n-3 DPA} Pathway Regulates Human Monocyte Differentiation and Macrophage Function.Cell Chem Biol. 2018 Jun 21;25(6):749-760.e9. doi: 10.1016/j.chembiol.2018.04.017.

• Dalli J, Serhan CN. Identification and structure elucidation of the pro-resolving mediators provides novel leads for resolution pharmacology. Br J Pharmacol. 2018 Apr 21. doi: 10.1111/bph.14336.

• Chiang N, Riley IR, Dalli J, Rodriguez AR, Spur BW, Serhan CN. New maresin conjugates in tissue regeneration pathway counters leukotriene D₄-stimulated vascular responses. FASEB J. 2018 Jul;32(7):4043-4052. doi: 10.1096/fj.201701493R.

• Chen J, Hamers AJP, Finsterbusch M, Massimo G, Zafar M, Corder R, Colas RA, Dalli J, Thiemermann C, Ahluwalia A. Endogenously generated arachidonate-derived ligands for TRPV1 induce cardiac protection in sepsis. FASEB J. 2018 Jul;32(7):3816-3831. doi: 10.1096/fj.201701303R.

• Colas RA, Souza PR, Walker ME, Burton M, Zasłona Z, Curtis AM, Marques RM, Dalli J. Impaired Production and Diurnal Regulation of Vascular RvD_{n-3 DPA} Increase Systemic Inflammation and Cardiovascular Disease. Circ Res. 2018 Mar 16;122(6):855-863. doi: 10.1161/CIRCRESAHA.117.312472.

• Dalli J, Colas RA, Walker ME, Serhan CN. Lipid Mediator Metabolomics Via LC-MS/MS Profiling and Analysis. Methods Mol Biol. 2018;1730:59-72. doi: 10.1007/978-1-4939-7592-1_4.

• Sulciner ML, Serhan CN, Gilligan MM, Mudge DK, Chang J, Gartung A, Lehner KA, Bielenberg DR, Schmidt B, Dalli J, Greene ER, Gus-Brautbar Y, Piwowarski J, Mammoto T, Zurakowski D, Perretti M, Sukhatme VP, Kaipainen A, Kieran MW, Huang S, Panigrahy D. Resolvins suppress tumor growth and enhance cancer therapy. J Exp Med. 2018 Jan 2;215(1):115-140. doi: 10.1084/jem.20170681.

• Dalli J, Serhan CN. Immunoresolvents signaling molecules at intersection between the brain and immune system. Curr Opin Immunol. 2018 Feb;50:48-54. doi: 10.1016/j.coi.2017.10.007.

2017

• Dakin SG, Ly L, Colas RA, Oppermann U, Wheway K, Watkins B, Dalli J, Carr AJ. Increased 15-PGDH expression leads to dysregulated resolution responses in stromal cells from patients with chronic tendinopathy. Sci Rep. 2017 Sep 8;7(1):11009. doi: 10.1038/s41598-017-11188-y.

• Walker ME, Souza PR, Colas RA, Dalli J. 13-Series resolvins mediate the leukocyte-platelet actions of atorvastatin and pravastatin in inflammatory arthritis. FASEB J. 2017 Aug;31(8):3636-3648. doi: 10.1096/fj.201700268.

• Dalli J. Does promoting resolution instead of inhibiting inflammation represent the new paradigm in treating infections? Mol Aspects Med. 2017 Dec;58:12-20. doi: 10.1016/j.mam.2017.03.007.

• Lee S, Nakahira K, Dalli J, Siempos II, Norris PC, Colas RA, Moon JS, Shinohara M, Hisata S, Howrylak JA, Suh GY, Ryter SW, Serhan CN, Choi AMK. NLRP3 Inflammasome Deficiency Protects against Microbial Sepsis via Increased Lipoxin B₄Synthesis. Am J Respir Crit Care Med. 2017 Sep 15;196(6):713-726. doi: 10.1164/rccm.201604-0892OC.

• Dalli J, Colas RA, Arnardottir H, Serhan CN. Vagal Regulation of Group 3 Innate Lymphoid Cells and the Immunoresolvent PCTR1 Controls Infection Resolution. Immunity. 2017 Jan 17;46(1):92-105. doi: 10.1016/j.immuni.2016.12.009.

• Freire MO, Dalli J, Serhan CN, Van Dyke TE. Neutrophil Resolvin E1 Receptor Expression and Function in Type 2 Diabetes. J Immunol. 2017 Jan 15;198(2):718-728. doi: 10.4049/jimmunol.1601543.

2016

• Colas RA, DalliJ, Chiang N, Vlasakov I, Sanger JM, Riley IR, Serhan CN. Identification and Actions of the Maresin 1 Metabolome in Infectious Inflammation. J Immunol. 2016 Dec 1;197(11):4444-4452.

• Rathod KS, Kapil V, Velmurugan S, Khambata RS, Siddique U, Khan S, Van Eijl S, Gee LC, Bansal J, Pitrola K, Shaw C, D’Acquisto F, Colas RA, Marelli-Berg F, Dalli J, Ahluwalia A. Accelerated resolution of inflammation underlies sex differences in inflammatory responses in humans. J Clin Invest. 2016 Nov 28. pii: 89429. doi: 10.1172/JCI89429.

• Dalli J, Vlasakov I, Riley IR, Rodriguez AR, Spur BW, Petasis NA, Chiang, N and Serhan CN. Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages. PNAS 2016 ; doi:10.1073/pnas.1607003113.

• Titos E, Rius B, López-Vicario C, Alcaraz-Quiles J, García-Alonso V, Lopategi A, Dalli J, Lozano JJ, Arroyo V, Delgado S, Serhan CN, Clària J. Signaling and Immunoresolving Actions of Resolvin D1 in Inflamed Human Visceral Adipose Tissue. J Immunol. 2016 Oct 15;197(8):3360-3370.

• Primdahl KG, Aursnes M, Walker ME, Colas RA, Serhan CN, Dalli J*, Hansen TV*, Vik A*. Synthesis of 13(R)-Hydroxy-7Z,10Z,13R,14E,16Z,19Z Docosapentaenoic Acid (13R-HDPA) and Its Biosynthetic Conversion to the 13-Series Resolvins. J Nat Prod. 2016 Oct 5.

• Arnardottir HH, Dalli J, Norling LV, Colas RA, Perretti M, Serhan CN. Resolvin D3 Is Dysregulated in Arthritis and Reduces Arthritic Inflammation. J Immunol. 2016 Sep 15;197(6):2362-8. doi: 10.4049/jimmunol.1502268.

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